Copic Ciao markers Packaged in a clear plastic case, a ciao set is the ideal way to begin or add to a marker collection.Refillable markers and replaceable nibs, compatible with copic air brush system.Alcohol-based ink is pemranent and non-toxic, dries acid free.Ciao 12-piece Basic Set. Scores of anime, manga, and comics artists as well as landscape, product, architecture, and fashion designers prefer Copic markers because of their ultra-blendable, low odor, alcohol based inks. Unlike water-based inks, which tend to pill and oversoak the paper while blending, Copics mix on the surface to deliver the wonderfully rich blends they are known for. This outstanding performance has distinguished Copic markers as the celebrated coloring tool within professional, semi-professional and hobby circles alike.