Femannose N D-MAH03A For the treatment and prevention of cystitis and other uncomplicated infections of the lower urinary tract 1. Description, composition and method of use of Femannose N 1.1 Mechanism of action Cystitis (inflammation of the bladder) and related conditions are microbial diseases that primarily affect the bladder and urethra. They are triggered mainly by the entry of non-pathogenic bacteria from the microflora of the lower gastrointestinal tract, when these bacteria fall into conditions that allow them to adhere and develop on the bladder wall and in the urinary tract. These conditions occur most often in young women, during pregnancy and during peri- and postmenopause, but sometimes occur in older men or catheterized patients. The current first-line therapy for the treatment of cystitis is the administration of antibiotics. However, many bacteria are resistant and can lead to the recurrence of infection. Femannose N is a medical device indicated for the treatment and prevention of cystitis and other uncomplicated bacterial infections of the lower urinary tract. D-mannose can relieve the most common symptoms of a lower urinary tract infection (burning during urination, frequent urination, urgency to urinate, etc.) when caused by E. coli-type bacteria. D-mannose is an epimer of glucose that effectively prevents pathogens from adhering to the urinary tract epithelium, thereby inhibiting the attachment of microbes that invade the urogenital tract. This reduces virulence or the ability to adhere to urinary tract tissues and helps physically prevent the recurrence of infections. Femannose N for the prevention or treatment of cystitis and other bacterial urinary tract infections may have a synergistic action along with antibiotics, since the antimicrobial mechanism of action is different and does not overlap. In particular, Femannose N and its constituents do not contribute to the development of resistance. 1.2 Composition Each sachet Contains: 2 g D-mannose (D-??????) Excipients: sweeteners: fructose, sucralose, citric acid; colorant: beets; anticaking agent: silica; Flavors. 2. Packaging One pack contains 14 sachets of 4 g each. 3. Dosage and instructions for use: For adults and children over 14 years of age. For the treatment of acute cystitis, the following dosage is recommended: Day Number of sachets per day 1 to 3 day 3 4 and 5 days 2 The recommended dose to prevent cystitis is one sachet per day. The intake should be distributed throughout the day. It is advisable to take the product between meals. Dissolve the contents of one sachet in a glass of water. It is advisable to drink at least two liters of water a day to stimulate urination. To prevent recurrence of infection, treatment should be continued for a month.